Volume 6 (2025) - Issue 1 (Aug 2025)

How is the HTT Mutation Expressed Differently in Primate Species as Compared to Homo Sapiens?

Cecelia Hengke Lin

Hong Kong International School, Sai Kung, Hong Kong 000000, Hong Kong
^*Authors to whom correspondence should be addressed.

Received: 2025-6-23 / Accepted: 2025-8-25 / Published: 2025-8-26

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DOI: https://doi.org/10.37906/isteamc.2025.02

Abstract This lab examines the evolutionary history of the HTT (huntingtin) gene using the Basic Local Alignment Search Tool (BLAST), which enables the comparison of DNA sequences across different species. The HTT gene provides instructions for creating the huntingtin protein, which is crucial for normal brain function. A mutation in this gene is the cause of Huntington’s disease. The DNA sequence comparison will also reveal the effects of specific mutations in the HTT gene on organisms in similar or dissimilar ways. A cladogram and other visuals will be included as evidence to support the conclusion.

Research Areas: Animals, Genetics, STEM

Keywords: Genetic disorder, Mutations, Biological organisms