Jeewon Chun *
George School, Newtown, Pennsylvania 18940, United States
*Authors to whom correspondence should be addressed.
Received: 2023-6-20 / Accepted: 2023-9-27 / Published: 2023-9-29
DOI: https://doi.org/10.37906/isteamc.2023.4
Abstract Alzheimer’s disease is the most common type of dementia affecting at least 27 million people. Recent connections have been observed between gut microbiota and brain health, highlighting the connection of the microbiota-gut-brain axis. Moreover, it has been shown that gut microbiota dysbiosis can affect Alzheimer’s pathology through the upregulation of NLRP3 inflammasome. Additionally, diet was shown to contribute to either a neural protective role or result in the progression of Alzheimer’s disease. The gut microbiota metabolites trimethyl amine oxide and select short-chain fatty acids were found to induce NLRP3 inflammasome recruitment, ultimately resulting in further aggravation of Alzheimer’s disease. In this review, we examined the influence the gut microbiota has on Alzheimer’s disease progression.
Research Areas: Health & Medicine, Neuroscience, Genetics, Microbes, STEM
Keywords: Alzheimer’s disease, gut microbiota, microbiota-gut-brain axis
