By  Jeewon Chun

Received: 2023-6-20 / Accepted: 2023-9-27 / Published: 2023-9-29

PDF Main Manuscript (346.6 KB)  DOI: https://doi.org/10.37906/isteamc.2023.4

Abstract Alzheimer’s disease is the most common type of dementia affecting at least 27 million people. Recent connections have been observed between gut microbiota and brain health, highlighting the connection of the microbiota-gut-brain axis. Moreover, it has been shown that gut microbiota dysbiosis can affect Alzheimer’s pathology through the upregulation of NLRP3 inflammasome. Additionally, diet was shown to contribute to either a neural protective role or result in the progression of Alzheimer’s disease. The gut microbiota metabolites trimethyl amine oxide and select short-chain fatty acids were found to induce NLRP3 inflammasome recruitment, ultimately resulting in further aggravation of Alzheimer’s disease. In this review, we examined the influence the gut microbiota has on Alzheimer’s disease progression. [More...]

By  Sophia Zhou, Yuxiang Sun

Received: 2023-7-15 / Accepted: 2023-9-27 / Published: 2023-9-29

PDF Main Manuscript (2.75 MB)  DOI: https://doi.org/10.37906/isteamc.2023.5

Abstract This study delves into housing unaffordability in New Zealand, examining income-to-housing cost ratios, affordability perceptions, contributing factors, mental health effects, and post-pandemic concerns. Findings highlight complex challenges shaped by income, region, demographics, and diverse perceptions. Income disparities, especially among lower-income non-property owners, underscore the need for targeted policies. Variations in affordability perceptions by ownership status, region, age, income, and ethnicity necessitate tailored strategies. Housing unaffordability negatively impacts mental health, particularly for aspiring non-owners, emphasising the importance of holistic policies. Post-pandemic housing market worries are prevalent among aspiring non-owners, varying by region, age, income, and ethnicity. Flexible policies are essential to address evolving market dynamics. In conclusion, New Zealand's housing affordability requires a comprehensive, inclusive approach. Policymakers must address income gaps, regional disparities, demographic diversity, and diverse perceptions to create a more equitable housing market promoting economic stability and mental well-being. [More...]